Papillary thyroid carcinoma tall cell variant shares accumulation of mitochondria, mitochondrial DNA mutations, and loss of oxidative phosphorylation complex I integrity with oncocytic tumors

Papillary thyroid carcinoma tall cell variant shares accumulation of mitochondria, mitochondrial DNA mutations, and loss of oxidative phosphorylation complex I integrity with oncocytic tumors

Abstract Papillary thyroid carcinoma tall cell variant (PTC‐TCV), a form of PTC regarded as an aggressive subtype, shares several morphologic features with oncocytic tumors. Pathogenic homoplasmic/highly heteroplasmic somatic mitochondrial DNA (mtDNA) mutations, usually affecting oxidative phosphory...

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Main Authors: Oleksiy Tsybrovskyy (Author), Monica De Luise (Author), Dario deBiase (Author), Leonardo Caporali (Author), Claudio Fiorini (Author), Giuseppe Gasparre (Author), Valerio Carelli (Author), Dominik Hackl (Author), Larisa Imamovic (Author), Silke Haim (Author), Manuel Sobrinho‐Simões (Author), Giovanni Tallini (Author)
Format: Book
Published: Wiley, 2022-03-01T00:00:00Z.
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