Redrawing Urokinase Receptor (uPAR) Signaling with Cancer Driver Genes for Exploring Possible Anti-Cancer Targets and Drugs

• Autori principali: Yu-Ching Chang (Autore), Chung-Ze Wu (Autore), Chao-Wen Cheng (Autore), Jin-Shuen Chen (Autore), Li-Chien Chang (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2023-10-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

During tumorigenesis, urokinase (uPA) and uPA receptor (uPAR) play essential roles in mediating pathological progression in many cancers. To understand the crosstalk between the uPA/uPAR signaling and cancer, as well as to decipher their cellular pathways, we proposed to use cancer driver genes to m...