Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy

• Main Authors: Cheng-Shi Jiang (Author), Chun-Lin Zhuang (Author), Kongkai Zhu (Author), Juan Zhang (Author), Luis Alexandre Muehlmann (Author), João Paulo Figueiró Longo (Author), Ricardo Bentes Azevedo (Author), Wen Zhang (Author), Ning Meng (Author), Hua Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new Keap1-Nrf2 protein-protein interaction (PPI) inhibitor ZJ01 was identified from our compound library by fluorescence polarization assay, surface plasmon resonance, molecular docking and molecular dynamics simulation. ZJ01 could in vitro trigger Nrf2 nuclear translocation, subsequently resultin...