Expression of intra- and extracellular granzymes in patients with typhoid fever.

• Main Authors: Hanna K de Jong (Author), Maria Isabel Garcia-Laorden (Author), Arie J Hoogendijk (Author), Christopher M Parry (Author), Rapeephan R Maude (Author), Arjen M Dondorp (Author), Mohammed Abul Faiz (Author), Tom van der Poll (Author), Willem Joost Wiersinga (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Typhoid fever, caused by the intracellular pathogen Salmonella (S.) enterica serovar Typhi, remains a major cause of morbidity and mortality worldwide. Granzymes are serine proteases promoting cytotoxic lymphocytes mediated eradication of intracellular pathogens via the induction of cell death and w...