Amino Acid Prodrugs: An Approach to Improve the Absorption of HIV-1 Protease Inhibitor, Lopinavir

• Main Authors: Mitesh Patel (Author), Nanda Mandava (Author), Mitan Gokulgandhi (Author), Dhananjay Pal (Author), Ashim K. Mitra (Author)
• Format: Book
• Published: MDPI AG, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Poor systemic concentrations of lopinavir (LPV) following oral administration occur due to high cellular efflux by P-glycoprotein (P-gp) and multidrug resistance-associated proteins (MRPs) and extensive metabolism by CYP3A4 enzymes. In this study, amino acid prodrugs of LPV were designed and investi...