Oral Administration of Artemisone for the Treatment of Schistosomiasis: Formulation Challenges and In Vivo Efficacy

• Main Authors: Johanna Zech (Author), Daniel Gold (Author), Nadeen Salaymeh (Author), Netanel Cohen Sasson (Author), Ithai Rabinowitch (Author), Jacob Golenser (Author), Karsten Mäder (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Artemisone is an innovative artemisinin derivative with applications in the treatment of malaria, schistosomiasis and other diseases. However, its low aqueous solubility and tendency to degrade after solubilisation limits the translation of this drug into clinical practice. We developed a self-micro...