Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis

• Main Authors: Lucia Tejedor-Santamaria (Author), Jose Luis Morgado-Pascual (Author), Laura Marquez-Exposito (Author), Beatriz Suarez-Alvarez (Author), Raul R. Rodrigues-Diez (Author), Antonio Tejera-Muñoz (Author), Vanessa Marchant (Author), Sergio Mezzano (Author), Carlos Lopez-Larrea (Author), Anna Sola (Author), Gema Maria Fernandez-Juarez (Author), Alberto Ortiz (Author), Sandra Rayego-Mateos (Author), Marta Ruiz-Ortega (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Crescentic glomerulonephritis is a devastating autoimmune disease that without early and properly treatment may rapidly progress to end-stage renal disease and death. Current immunosuppressive treatment provides limited efficacy and an important burden of adverse events. Epigenetic drugs are a sourc...