The ClC-2 Chloride Channel Activator, Lubiprostone, Improves Intestinal Barrier Function in Biopsies from Crohn's Disease but Not Ulcerative Colitis Patients

• Main Authors: Young Su Park (Author), Sang Bum Kang (Author), Ronald R. Marchelletta (Author), Harrison M. Penrose (Author), Roos Ruiter-Visser (Author), Barbara Jung (Author), Michael J. Docherty (Author), Brigid S. Boland (Author), William J. Sandborn (Author), Declan F. McCole (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The prostone analog, lubiprostone, is approved to manage constipation-predominant irritable bowel syndrome. Lubiprostone also protects intestinal mucosal barrier function in animal models of colitis. The aim of this study was to determine if lubiprostone improves barrier properties in isolated colon...