Spatiotemporal Mapping Techniques Show Clozapine Impairs Neurogenic and Myogenic Patterns of Activity in the Colon of the Rabbit in a Dose-Dependent Manner

• Ngā kaituhi matua: Roger G. Lentle (Author), Susanna Every-Palmer (Author), Gordon Reynolds (Author), Corrin Hulls (Author), Paul Chambers (Author), Helen Dunn (Author), Pete M. Ellis (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2017-04-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Background: Clozapine, an antipsychotic used in treatment-resistant schizophrenia, has adverse gastrointestinal effects with significant associated morbidity and mortality. However, its effects on defined patterns of colonic contractile activity have not been assessed.Method: We used novel radial an...