PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space

PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space

Abstract Patients with severe and sometimes moderate hemophilia B are prophylactically treated with factor IX concentrates to prevent bleeding. For some time now, various extended terminal half‐life (EHL) recombinant factor IX concentrates are available allowing less frequent administration during p...

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Main Authors: Michael E. Cloesmeijer (Author), Erik Sjögren (Author), Sjoerd F. Koopman (Author), Peter. J. Lenting (Author), Marjon H. Cnossen (Author), Ron A. A. Mathôt (Author), the OPTI‐CLOT study group and SYMPHONY consortium (Author)
Format: Book
Published: Wiley, 2024-10-01T00:00:00Z.
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3rd Floor Main Library

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