Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

• Main Authors: Xu Wu (Author), Chun Yin (Author), Jiang Ma (Author), Stella Chai (Author), Chunyuan Zhang (Author), Sheng Yao (Author), Onat Kadioglu (Author), Thomas Efferth (Author), Yang Ye (Author), Kenneth Kin-Wah To (Author), Ge Lin (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and d...