Crosstalk between Long-Term Sublethal Oxidative Stress and Detrimental Inflammation as Potential Drivers for Age-Related Retinal Degeneration

• Main Authors: Lara Macchioni (Author), Davide Chiasserini (Author), Letizia Mezzasoma (Author), Magdalena Davidescu (Author), Pier Luigi Orvietani (Author), Katia Fettucciari (Author), Leonardo Salviati (Author), Barbara Cellini (Author), Ilaria Bellezza (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Age-related retinal degenerations, including age-related macular degeneration (AMD), are caused by the loss of retinal pigmented epithelial (RPE) cells and photoreceptors. The pathogenesis of AMD, deeply linked to the aging process, also involves oxidative stress and inflammatory responses. However,...