First‐in‐human development of a pharmacodynamic biomarker for PAC1 receptor antagonists using intradermal injections of maxadilan

• প্রধান লেখক: Heleen Marynissen (লেখক), Linde Buntinx (লেখক), Dorien Bamps (লেখক), Marleen Depre (লেখক), Els Ampe (লেখক), Anne Van Hecken (লেখক), Kristin Gabriel (লেখক), Steve Sands (লেখক), Gabriel Vargas (লেখক), Jan de Hoon (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2022-08-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Maxadilan, a potent vasodilator peptide, selectively activates the PAC1 receptor, a promising target for migraine therapy. Therefore, maxadilan has been suggested as a tool to study the pharmacodynamics (PDs) of PAC1 receptor antagonists. The objectives of this first‐in‐human study were to:...