Intrathecal long-term gene expression by self-complementary adeno-associated virus type 1 suitable for chronic pain studies in rats

• Main Authors: Janssen William GM (Author), McCarty Douglas M (Author), Wang Cheng (Author), Banck Michaela S (Author), Harder Nina M (Author), Storek Benjamin (Author), Morrison John H (Author), Walsh Christopher E (Author), Beutler Andreas S (Author)
• Format: Book
• Published: SAGE Publishing, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Intrathecal (IT) gene transfer is an attractive approach for targeting spinal mechanisms of nociception but the duration of gene expression achieved by reported methods is short (up to two weeks) impairing their utility in the chroni...