Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice

• Main Authors: Shailendra P. Singh (Author), Shixin Tao (Author), Timothy A. Fields (Author), Sydney Webb (Author), Raymond C. Harris (Author), Reena Rao (Author)
• Format: Book
• Published: The Company of Biologists, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glycogen synthase kinase-3β (GSK3β) is a serine/threonine protein kinase that plays an important role in renal tubular injury and regeneration in acute kidney injury. However, its role in the development of renal fibrosis, often a long-term consequence of acute kidney injury, is unknown. Using a mou...