Base-modified aptamers obtained by cell-internalization SELEX facilitate cellular uptake of an antisense oligonucleotide

• Main Authors: Keisuke Tanaka (Author), Takumi Okuda (Author), Yuuya Kasahara (Author), Satoshi Obika (Author)
• Formato: Livro
• Publicado em: Elsevier, 2021-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Intracellular delivery of oligonucleotides is important for their use as therapeutic drugs. The conjugation of molecules interacting with cell membrane proteins to enhance their internalization into cells is an effective strategy for delivering oligonucleotides. In the present study, we focused on c...