Base-modified aptamers obtained by cell-internalization SELEX facilitate cellular uptake of an antisense oligonucleotide

• 主要な著者: Keisuke Tanaka (著者), Takumi Okuda (著者), Yuuya Kasahara (著者), Satoshi Obika (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2021-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Intracellular delivery of oligonucleotides is important for their use as therapeutic drugs. The conjugation of molecules interacting with cell membrane proteins to enhance their internalization into cells is an effective strategy for delivering oligonucleotides. In the present study, we focused on c...