Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors

• Main Authors: Cheng-Zhi Gao (Author), Wei Dong (Author), Zhi-Wen Cui (Author), Qiong Yuan (Author), Xia-Min Hu (Author), Qing-Ming Wu (Author), Xianlin Han (Author), Yao Xu (Author), Zhen-Li Min (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of new Olaparib derivatives was designed and synthesized, and their inhibitory activities against poly (ADP-ribose) polymerases-1 (PARP-1) enzyme and cancer cell line MDA-MB-436 in vitro were evaluated. The results showed that compound 5l exhibited the most potent inhibitory effects on PARP...