A Mechanistic In Vivo/Ex Vivo Pharmacokinetic‐Pharmacodynamic Model of Tenofovir for HIV Prevention

• Autori principali: Priya Jayachandran (Autore), Maria Garcia-Cremades (Autore), Katarina Vučićević (Autore), Namandjé N. Bumpus (Autore), Peter Anton (Autore), Craig Hendrix (Autore), Radojka Savić (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2021-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Defining tissue and plasma‐specific prophylactic drug concentrations is central to pre‐exposure prophylaxis product development for sexual transmission of HIV‐1. Pharmacokinetic (PK) data from study RMP‐02/MTN‐006 comparing single dose oral tenofovir disoproxil fumarate with single and multiple dose...