Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity

• Egile Nagusiak: Neal Anthwal (Egilea), Michelle Pelling (Egilea), Suzanne Claxton (Egilea), Georg Mellitzer (Egilea), Caitlin Collin (Egilea), Nicoletta Kessaris (Egilea), William D. Richardson (Egilea), Gérard Gradwohl (Egilea), Siew-Lan Ang (Egilea)
• Formatua: Liburua
• Argitaratua: The Company of Biologists, 2013-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

SUMMARY The ventral hypothalamus acts to integrate visceral and systemic information to control energy balance. The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3) is required for pancreatic β-cell development and has been implicated in neuronal development in the hypothalamus. Here,...