Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity

• Main Authors: Neal Anthwal (Author), Michelle Pelling (Author), Suzanne Claxton (Author), Georg Mellitzer (Author), Caitlin Collin (Author), Nicoletta Kessaris (Author), William D. Richardson (Author), Gérard Gradwohl (Author), Siew-Lan Ang (Author)
• Format: Book
• Published: The Company of Biologists, 2013-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY The ventral hypothalamus acts to integrate visceral and systemic information to control energy balance. The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3) is required for pancreatic β-cell development and has been implicated in neuronal development in the hypothalamus. Here,...