Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity

• Hoofdauteurs: Neal Anthwal (Auteur), Michelle Pelling (Auteur), Suzanne Claxton (Auteur), Georg Mellitzer (Auteur), Caitlin Collin (Auteur), Nicoletta Kessaris (Auteur), William D. Richardson (Auteur), Gérard Gradwohl (Auteur), Siew-Lan Ang (Auteur)
• Formaat: Boek
• Gepubliceerd in: The Company of Biologists, 2013-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

SUMMARY The ventral hypothalamus acts to integrate visceral and systemic information to control energy balance. The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3) is required for pancreatic β-cell development and has been implicated in neuronal development in the hypothalamus. Here,...