Pharmacological correctors of mutant CFTR mistrafficking

• Główni autorzy: Nicoletta ePedemonte (Autor), Luis eGalietta (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2012-10-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The lack of phenylalanine 508 (∆F508 mutation) in the CFTR Cl- channel represents the most frequent cause of cystic fibrosis (CF), a genetic disease affecting multiple organs such lung, pancreas, and liver. ∆F508 causes instability and misfolding of CFTR protein leading to early degradation in the e...