Pharmacological correctors of mutant CFTR mistrafficking
The lack of phenylalanine 508 (∆F508 mutation) in the CFTR Cl- channel represents the most frequent cause of cystic fibrosis (CF), a genetic disease affecting multiple organs such lung, pancreas, and liver. ∆F508 causes instability and misfolding of CFTR protein leading to early degradation in the e...
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| Main Authors: | , |
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| Format: | Book |
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Frontiers Media S.A.,
2012-10-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |