Synthesis and preliminary structure-activity relationship study of 2-aryl-2H-pyrazolo[4,3-c]quinolin-3-ones as potential checkpoint kinase 1 (Chk1) inhibitors

• मुख्य लेखकों: Ivana Malvacio (लेखक), Alberto Cuzzolin (लेखक), Mattia Sturlese (लेखक), D. Mariano A. Vera (लेखक), E. Laura Moyano (लेखक), Stefano Moro (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The serine-threonine checkpoint kinase 1 (Chk1) plays a critical role in the cell cycle arrest in response to DNA damage. In the last decade, Chk1 inhibitors have emerged as a novel therapeutic strategy to potentiate the anti-tumour efficacy of cytotoxic chemotherapeutic agents. In the search for ne...