Synthesis and preliminary structure-activity relationship study of 2-aryl-2H-pyrazolo[4,3-c]quinolin-3-ones as potential checkpoint kinase 1 (Chk1) inhibitors

• Главные авторы: Ivana Malvacio (Автор), Alberto Cuzzolin (Автор), Mattia Sturlese (Автор), D. Mariano A. Vera (Автор), E. Laura Moyano (Автор), Stefano Moro (Автор)
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• Опубликовано: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Предметы: article
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The serine-threonine checkpoint kinase 1 (Chk1) plays a critical role in the cell cycle arrest in response to DNA damage. In the last decade, Chk1 inhibitors have emerged as a novel therapeutic strategy to potentiate the anti-tumour efficacy of cytotoxic chemotherapeutic agents. In the search for ne...