Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

• Main Authors: S. Lindsey eDavis (Author), Kelli M. Robertson (Author), Todd M. Pitts (Author), John J. Tentler (Author), Erica L. Bradshaw-Pierce (Author), Peter J. Klauck (Author), Stacey M. Bagby (Author), Stephanie L. Hyatt (Author), Heather M. Selby (Author), Anna eSpreafico (Author), Jeffrey A Ecsedy (Author), John J. Arcaroli (Author), Wells A. Messersmith (Author), Aik Choon eTan (Author), S. Gail eEckhardt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aurora A kinase and MEK inhibitors induce different, and potentially complementary, effects on the cell cycle of malignant cells, suggesting a rational basis for utilizing these agents in combination. In this work, the combination of an Aurora A kinase and MEK inhibitor was evaluated in pre-clinical...