Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models

• Principais autores: S. Lindsey eDavis (Autor), Kelli M. Robertson (Autor), Todd M. Pitts (Autor), John J. Tentler (Autor), Erica L. Bradshaw-Pierce (Autor), Peter J. Klauck (Autor), Stacey M. Bagby (Autor), Stephanie L. Hyatt (Autor), Heather M. Selby (Autor), Anna eSpreafico (Autor), Jeffrey A Ecsedy (Autor), John J. Arcaroli (Autor), Wells A. Messersmith (Autor), Aik Choon eTan (Autor), S. Gail eEckhardt (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2015-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Aurora A kinase and MEK inhibitors induce different, and potentially complementary, effects on the cell cycle of malignant cells, suggesting a rational basis for utilizing these agents in combination. In this work, the combination of an Aurora A kinase and MEK inhibitor was evaluated in pre-clinical...