Physiologically‐based pharmacokinetic modeling to predict CYP3A4‐mediated drug‐drug interactions of finerenone

• Main Authors: Thomas Wendl (Author), Sebastian Frechen (Author), Michael Gerisch (Author), Roland Heinig (Author), Thomas Eissing (Author)
• Formato: Libro
• Publicado: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Abstract Finerenone is a nonsteroidal, selective mineralocorticoid receptor antagonist that recently demonstrated its efficacy to delay chronic kidney disease (CKD) progression and reduce cardiovascular events in patients with CKD and type 2 diabetes. Here, we report the development of a physiologic...