Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques.

• Main Authors: Rebecca Broeckel (Author), Julie M Fox (Author), Nicole Haese (Author), Craig N Kreklywich (Author), Soila Sukulpovi-Petty (Author), Alfred Legasse (Author), Patricia P Smith (Author), Michael Denton (Author), Carsten Corvey (Author), Shiv Krishnan (Author), Lois M A Colgin (Author), Rebecca M Ducore (Author), Anne D Lewis (Author), Michael K Axthelm (Author), Marie Mandron (Author), Pierre Cortez (Author), Jonathan Rothblatt (Author), Ercole Rao (Author), Ingo Focken (Author), Kara Carter (Author), Gopal Sapparapau (Author), James E Crowe (Author), Michael S Diamond (Author), Daniel N Streblow (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chikungunya virus (CHIKV) is a mosquito-borne virus that causes a febrile syndrome in humans associated with acute and chronic debilitating joint and muscle pain. Currently no licensed vaccines or therapeutics are available to prevent or treat CHIKV infections. We recently isolated a panel of potent...