Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blockers

• Main Authors: Hiroko Izumi-Nakaseko (Author), Mihoko Hagiwara-Nagasawa (Author), Atsuhiko T. Naito (Author), Ai Goto (Author), Koki Chiba (Author), Yuko Sekino (Author), Yasunari Kanda (Author), Atsushi Sugiyama (Author)
• Format: Book
• Published: Elsevier, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined electrophysiological indices of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) sheets in order to quantitatively estimate Na+, K+ and Ca2+ channel blocking actions of bepridil and amiodarone using microelectrode array system in comparison with that of E-4031. We a...