Targeting thymidine phosphorylase as a potential therapy for bone loss associated with periprosthetic osteolysis

• Main Authors: Gen Matsumae (Author), Tomohiro Shimizu (Author), Yuan Tian (Author), Daisuke Takahashi (Author), Taku Ebata (Author), Hend Alhasan (Author), Shunichi Yokota (Author), Ken Kadoya (Author), Mohamad Alaa Terkawi (Author), Norimasa Iwasaki (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Macrophages are generally thought to play a key role in the pathogenesis of aseptic loosening through initiating periprosthetic inflammation and pathological bone resorption. The aim of this study was to identify macrophage‐derived factors that promote osteoclast differentiation and peripro...