Case Report: Safety and Efficacy of Denosumab in Four Children With Noonan Syndrome With Multiple Giant Cell Lesions of the Jaw

• প্রধান লেখক: Kristen Ferriero (লেখক), Biraj Shah (লেখক), Yun Yan (লেখক), Surya Khatri (লেখক), John Caccamese (লেখক), Joseph A. Napoli (লেখক), Michael B. Bober (লেখক), Janet L. Crane (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Noonan syndrome is a genetic disorder caused by mutations in the RAS/MAPK pathway. Multiple giant cell lesions are a rare sequelae of disruptions in this pathway, termed Noonan-like multiple giant cell lesions (NL/MGCLs). Medical management of these tumors rather than surgical intervention is prefer...