In Vitro Efficacy and Molecular Mechanism of Curcumin Analog in Pathological Regulation of Spinocerebellar Ataxia Type 3

Unlike other nuclear factor erythroid-2-related factor 2 (Nrf2) activators, the mechanism of action of curcumin analog, ASC-JM17 (JM17), in regulating oxidative homeostasis remains unknown. Spinocerebellar ataxia type 3 (SCA3) is an inherited polyglutamine neurodegenerative disease caused mainly by...

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Main Authors: Yu-Ling Wu (Author), Jui-Chih Chang (Author), Yi-Chun Chao (Author), Hardy Chan (Author), Mingli Hsieh (Author), Chin-San Liu (Author)
Format: Book
Published: MDPI AG, 2022-07-01T00:00:00Z.
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