Mechanisms Underlying the Action of Ziziphi Spinosae Semen in the Treatment of Insomnia: A Study Involving Network Pharmacology and Experimental Validation

• Main Authors: Zhenhua Bian (Author), Wenming Zhang (Author), Jingyue Tang (Author), Qianqian Fei (Author), Minmin Hu (Author), Xiaowei Chen (Author), Lianlin Su (Author), Chenghao Fei (Author), De Ji (Author), Chunqin Mao (Author), Huangjin Tong (Author), Xiaohang Yuan (Author), Tulin Lu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: This study aimed to investigate the potential mechanisms and related bioactive components of ZSS for the treatment of insomnia.Method: The insomnia model of rat induced by PCPA was established. After oral administration of ZSS extract, the general morphological observation, pentobarbital so...