Preclinical Evaluation of the Tumorigenic and Immunomodulatory Properties of Human Bone Marrow Mesenchymal Stromal Cell Populations with Clonal Trisomy 5

• Main Authors: Maria Susana Joya Marodin (Author), Juliana A. Godoy (Author), Raquel M. Alves-Paiva (Author), Kelen Alvarez (Author), Thiago Giove Mitsugi (Author), Ana Cristina Victorino Krepischi (Author), Nelson Hamerschlak (Author), Maria Augusta Tezelli Bortolini (Author), Rodrigo Castro (Author), Andrea T. Kondo (Author), Jose Mauro Kutner (Author), Oswaldo Keith Okamoto (Author)
• Format: Book
• Published: Hindawi Limited, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytogenetic aberrations may emerge in human mesenchymal stromal cells (MSC) during ex vivo expansion for cell therapy. We have detected clonal trisomy 5 in two distinct autologous MSC products expanded from bone marrow which, based on the current quality control criteria, could not be released for c...