UHRF1/DNMT1-MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer

• Main Authors: Shuye Lin (Author), Hanli Xu (Author), Lin Qin (Author), Mengdi Pang (Author), Ziyu Wang (Author), Meng Gu (Author), Lishu Zhang (Author), Cong Zhao (Author), Xuefeng Hao (Author), Zhiyun Zhang (Author), Weimin Ding (Author), Jianke Ren (Author), Jiaqiang Huang (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As confusion mounts over RNA isoforms involved in phenotypic plasticity, aberrant CpG methylation-mediated disruption of alternative splicing is increasingly recognized as a driver of intratumor heterogeneity (ITH). Protease serine 3 (PRSS3), possessing four splice variants (PRSS3-SVs; PRSS3-V1-V4),...