Development of spray-dried amorphous solid dispersions of tadalafil using glycyrrhizin for enhanced dissolution and aphrodisiac activity in male rats

• Main Authors: Mohammed Muqtader Ahmed (Author), Farhat Fatima (Author), Mohd Abul Kalam (Author), Aws Alshamsan (Author), Gamal A. Soliman (Author), Abdul Azim Shaikh (Author), Saad M Alshahrani (Author), Mohammed F. Aldawsari (Author), Saurabh Bhatia (Author), Md. Khalid Anwer (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tadalafil (TDL) is a phosphodiesterase-5 inhibitor (PDE5I), indicated for erectile dysfunction (ED). However, TDL exhibits poor aqueous solubility and dissolution rate, which may limit its application. This study aims to prepare amorphous solid dispersion (ASD) by spray-drying, using glycyrrhizin-a...