A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation

• Main Authors: Alessandro Mega (Author), Aman Mebrahtu (Author), Gustav Aniander (Author), Eva Ryer (Author), Annette Sköld (Author), Anna Sandegren (Author), Eva Backström Rydin (Author), Johan Rockberg (Author), Arne Östman (Author), Fredrik Y. Frejd (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTCD40 agonism by systemic administration of CD40 monoclonal antibodies has been explored in clinical trials for immunotherapy of cancer, uncovering enormous potential, but also dosing challenges in terms of systemic toxicity. CD40-dependent activation of antigen presenting cells is dependent...