Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route

• Main Authors: Chunyan Jia (Author), Su Su Lei Mon (Author), Ying Yang (Author), Maho Katsuyama (Author), Kie Yoshida-Tanaka (Author), Tetsuya Nagata (Author), Kotaro Yoshioka (Author), Takanori Yokota (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antisense oligonucleotides (ASOs) are promising therapeutics for intractable central nervous system (CNS) diseases. For this clinical application, neurotoxicity is one of the critical limitations. Therefore, an evaluation of this neurotoxicity from a behavioral perspective is important to reveal sym...