Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development

• Main Authors: Kristin M. Ates (Author), Tong Wang (Author), Trevor Moreland (Author), Rajalakshmi Veeranan-Karmegam (Author), Manxiu Ma (Author), Chelsi Jeter (Author), Priya Anand (Author), Wolfgang Wenzel (Author), Hyung-Goo Kim (Author), Lynne A. Wolfe (Author), Joshi Stephen (Author), David R. Adams (Author), Thomas Markello (Author), Cynthia J. Tifft (Author), Robert Settlage (Author), William A. Gahl (Author), Graydon B. Gonsalvez (Author), May Christine Malicdan (Author), Heather Flanagan-Steet (Author), Y. Albert Pan (Author)
• Format: Book
• Published: The Company of Biologists, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A critical barrier in the treatment of endosomal and lysosomal diseases is the lack of understanding of the in vivo functions of the putative causative genes. We addressed this by investigating a key pair of endocytic adaptor proteins, PH domain-containing endocytic trafficking adaptor 1 and 2 (PHET...