Assessment of 5-HT7 Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice

• Main Authors: Alex Brenchat (Author), Maria Rocasalbas (Author), Daniel Zamanillo (Author), Michel Hamon (Author), José Miguel Vela (Author), Luz Romero (Author)
• Format: Knjiga
• Izdano: Hindawi Limited, 2012-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

No study has ever examined the effect of 5-HT7 receptor agonists on nociception by using 5-HT7 receptor knockout mice. Basal sensitivity to noxious heat stimuli and formalin-induced nociception in both phase I and II of the formalin test did not differ in 5-HT7 receptor knockout mice and paired wild...