Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies

• Main Authors: P. A. Goldsteen (Author), A. M. Sabogal Guaqueta (Author), P. P. M. F. A. Mulder (Author), I. S. T. Bos (Author), M. Eggens (Author), L. Van der Koog (Author), J. T. Soeiro (Author), A. J. Halayko (Author), K. Mathwig (Author), L. E. M. Kistemaker (Author), E. M. J. Verpoorte (Author), A. M. Dolga (Author), R. Gosens (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Airway cholinergic nerves play a key role in airway physiology and disease. In asthma and other diseases of the respiratory tract, airway cholinergic neurons undergo plasticity and contribute to airway hyperresponsiveness and mucus secretion. We currently lack human in vitro models for airway cholin...