Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors

• Main Authors: Lien Wang (Author), Grace Lee (Author), Amy Shih (Author), Chester Kuei (Author), Diane Nepomuceno (Author), Michelle Wennerholm (Author), Frances Fan (Author), Jiejun Wu (Author), Pascal Bonaventure (Author), Timothy W. Lovenberg (Author), Changlu Liu (Author)
• Format: Book
• Published: Wiley, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract GPR139 is a Gq‐coupled receptor activated by the essential amino acids L‐tryptophan (L‐Trp) and L‐phenylalanine (L‐Phe). We carried out mutagenesis studies of the human GPR139 receptor to identify the critical structural motifs required for GPR139 activation. We applied site‐directed and hi...