MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production.

• Main Authors: Xun Zhu (Author), Zhenjian He (Author), Yiwen Hu (Author), Weitao Wen (Author), Cuiji Lin (Author), Jianchen Yu (Author), Jing Pan (Author), Ran Li (Author), Haijing Deng (Author), Shaowei Liao (Author), Jie Yuan (Author), Jueheng Wu (Author), Jun Li (Author), Mengfeng Li (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNAs have been shown to contribute to a repertoire of host-pathogen interactions during viral infection. Our previous study demonstrated that microRNA-30e* (miR-30e*) directly targeted the IκBα 3'-UTR and disrupted the NF-κB/IκBα negative feedback loop, leading to hyperactivation of NF-κB....