The Application of Global Sensitivity Analysis in the Development of a Physiologically Based Pharmacokinetic Model for m-Xylene and Ethanol Co-Exposure in Humans

• Main Authors: George D Loizou (Author), Kevin eMcNally (Author), Kate eJones (Author), John eCocker (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Global sensitivity analysis (SA) was used during the development phase of a binary chemical physiologically based pharmacokinetic (PBPK) model used for the analysis of m-xylene and ethanol co-exposure in humans. SA was used to identify those parameters which had the most significant impact on variab...