The Application of Global Sensitivity Analysis in the Development of a Physiologically Based Pharmacokinetic Model for m-Xylene and Ethanol Co-Exposure in Humans

• 主要な著者: George D Loizou (著者), Kevin eMcNally (著者), Kate eJones (著者), John eCocker (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2015-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Global sensitivity analysis (SA) was used during the development phase of a binary chemical physiologically based pharmacokinetic (PBPK) model used for the analysis of m-xylene and ethanol co-exposure in humans. SA was used to identify those parameters which had the most significant impact on variab...