The Application of Global Sensitivity Analysis in the Development of a Physiologically Based Pharmacokinetic Model for m-Xylene and Ethanol Co-Exposure in Humans

• Váldodahkkit: George D Loizou (Dahkki), Kevin eMcNally (Dahkki), Kate eJones (Dahkki), John eCocker (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2015-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Global sensitivity analysis (SA) was used during the development phase of a binary chemical physiologically based pharmacokinetic (PBPK) model used for the analysis of m-xylene and ethanol co-exposure in humans. SA was used to identify those parameters which had the most significant impact on variab...