Blockade of Inflammation and Apoptosis Pathways by siRNA Prolongs Cold Preservation Time and Protects Donor Hearts in a Porcine Model

• Autors principals: Jia Wei (Autor), Shiyou Chen (Autor), Song Xue (Autor), Qiangru Zhu (Autor), Sha Liu (Autor), Li Cui (Autor), Xiuguo Hua (Autor), Yongyi Wang (Autor)
• Format: Llibre
• Publicat: Elsevier, 2017-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

In donor hearts from mini pigs, overtime cold preservation and ischemia-reperfusion injury cause poor graft quality and impaired heart function. Blockage of complement, apoptosis, and inflammation is considered a strategy for attenuating ischemia-reperfusion injury and protecting cardiac function. M...