Immunogenicity, safety and reactogenicity of heterologous (third dose) booster vaccination with a full or fractional dose of two different COVID-19 vaccines: A phase 4, single-blind, randomized controlled trial in adults

• Main Authors: Sue Ann Costa Clemens (Author), Natalie Marchevsky (Author), Sarah Kelly (Author), Sally Felle (Author), Ahmed Eldawi (Author), Rupetha Rajasingam (Author), Rawan Mahmud (Author), Teresa Lambe (Author), Merryn Voysey (Author), Isabela Gonzalez (Author), Eveline Pipolo Milan (Author), Maria Cleonice Justino (Author), Sagida Bibi (Author), Parvinder Aley (Author), Ralf Clemens (Author), Andrew J. Pollard (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this phase 4 study we assessed boosting with fractional doses of heterologous COVID-19 vaccines in Brazilian adults primed with two doses of CoronaVac (Sinovac/Butantan, São Paulo, Brazil) at least 4 months previously. Participants received either full-dose of ChAdOx1-S (Group 1, n = 232), a half...