Characterization of viral insulins reveals white adipose tissue-specific effects in mice

• Main Authors: Martina Chrudinová (Author), François Moreau (Author), Hye Lim Noh (Author), Terezie Páníková (Author), Lenka Žáková (Author), Randall H. Friedline (Author), Francisco A. Valenzuela (Author), Jason K. Kim (Author), Jiří Jiráček (Author), C. Ronald Kahn (Author), Emrah Altindis (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Members of the insulin/insulin-like growth factor (IGF) superfamily are well conserved across the evolutionary tree. We recently showed that four viruses in the Iridoviridae family possess genes that encode proteins highly homologous to human insulin/IGF-1. Using chemically synthesized si...