Therapeutic Potentials of Selected Antihypertensive Agents and Their Fixed-Dose Combinations Against Trastuzumab-Mediated Cardiotoxicity

• Main Authors: Olufunke Esan Olorundare (Author), Adejuwon Adewale Adeneye (Author), Akinyele Olubiyi Akinsola (Author), Abayomi Mayowa Ajayi (Author), Olalekan Ayodele Agede (Author), Sunday Sokunle Soyemi (Author), Alban Ikenna Mgbehoma (Author), Ikechukwu Innocent Okoye (Author), Ralph M. Albrecht (Author), James Mukasa Ntambi (Author), Peter Anthony Crooks (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trastuzumab (TZM) is useful in the clinical management of HER2-positive metastatic breast, gastric, and colorectal carcinoma but has been limited by its off-target cardiotoxicity. This study investigates the therapeutic potentials of 0.25 mg/kg/day amlodipine, 0.035 mg/kg/day lisinopril, 5 mg/kg/day...