N-acetylcysteine alleviates post-resuscitation myocardial dysfunction and improves survival outcomes via partly inhibiting NLRP3 inflammasome induced-pyroptosis

• Main Authors: Fenglian He (Author), Guanghui Zheng (Author), Jingying Hou (Author), Qiaohua Hu (Author), Qin Ling (Author), Gongfa Wu (Author), Hui Zhao (Author), Jin Yang (Author), Yue Wang (Author), Longyuan Jiang (Author), Wanchun Tang (Author), Zhengfei Yang (Author)
• Format: Book
• Published: BMC, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background NOD-like receptor 3 (NLRP3) inflammasome is necessary to initiate acute sterile inflammation. Increasing evidence indicates the activation of NLRP3 inflammasome induced pyroptosis is closely related to reactive oxygen species (ROS) in the sterile inflammatory response triggered b...