Amino acid homeostasis is a target of metformin therapy

• Main Authors: Calum Forteath (Author), Ify Mordi (Author), Raid Nisr (Author), Erika J. Gutierrez-Lara (Author), Noor Alqurashi (Author), Iain R. Phair (Author), Amy R. Cameron (Author), Craig Beall (Author), Ibrahim Bahr (Author), Mohapradeep Mohan (Author), Aaron K.F. Wong (Author), Adel Dihoum (Author), Anwar Mohammad (Author), Colin N.A. Palmer (Author), Douglas Lamont (Author), Kei Sakamoto (Author), Benoit Viollet (Author), Marc Foretz (Author), Chim C. Lang (Author), Graham Rena (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Unexplained changes in regulation of branched chain amino acids (BCAA) during diabetes therapy with metformin have been known for years. Here we have investigated mechanisms underlying this effect. Methods: We used cellular approaches, including single gene/protein measurements, as well a...