Lansoprazole-induced osteoporosis via the IP3R- and SOCE-mediated calcium signaling pathways

• Main Authors: Ziping Cheng (Author), Yangjie Liu (Author), Mengyuan Ma (Author), Shiyu Sun (Author), Zengqing Ma (Author), Yu Wang (Author), Liyuan Yu (Author), Xuping Qian (Author), Luning Sun (Author), Xuehui Zhang (Author), Yun Liu (Author), Yongqing Wang (Author)
• Format: Book
• Published: BMC, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Many clinical studies have shown a correlation between proton pump inhibitors (PPIs) and osteoporosis or fractures. The purpose of this study was to establish a murine model of chronic oral PPI administration to verify whether PPIs caused bone metabolic impairment and investigate...