ERα down-regulation plays a key role in silibinin-induced autophagy and apoptosis in human breast cancer MCF-7 cells

• Main Authors: Nan Zheng (Author), Ping Zhang (Author), Huai Huang (Author), Weiwei Liu (Author), Toshihiko Hayashi (Author), Linghe Zang (Author), Ye Zhang (Author), Lu Liu (Author), Mingyu Xia (Author), Shin-ichi Tashiro (Author), Satoshi Onodera (Author), Takashi Ikejima (Author)
• Format: Book
• Published: Elsevier, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The estrogen receptor alpha (ERα) has been proven to be one of the most important therapeutic targets in breast cancer over the last 30 years. Previous studies pointed out that a natural flavonoid, silibinin, induced apoptosis in human breast cancer MCF-7 cells. In the present study we report that e...