In vitro pharmacokinetics/pharmacodynamics of FL058 (a novel beta-lactamase inhibitor) combined with meropenem against carbapenemase-producing Enterobacterales

• Main Authors: Zhiwei Huang (Author), Xingchen Bian (Author), Yi Li (Author), Jiali Hu (Author), Beining Guo (Author), Xinyi Yang (Author), Yi Jin (Author), Shansong Zheng (Author), Xinmei Wang (Author), Cong Gao (Author), Jing Zhang (Author), Xiaojie Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: FL058 is a novel beta-lactamase inhibitor with a broad spectrum of activity and a favorable safety profile. The objective of this study was to evaluate pharmacokinetic/pharmacodynamic (PK/PD) relationships for the combination of FL058 and meropenem in an in vitro infection model.Methods:...